At PMEC India, the one-stop solutions provider Romaco will present selected technologies for granulation, tableting and primary packaging of pharmaceutical solid dosage forms. From laboratory equipment to high-performance production systems, and from standalone machines to turnkey lines, Romaco offers the right solution for every application.
Romaco Noack N 950E blister packaging machine
The N 950E is an ultra-flexible, easy-to-use blister packaging machine with rotary sealing for the high-speed segment. The blisters can be conveyed both longitudinally and crosswise, with the machine achieving a maximum output of 500 blisters a minute. It has a compact design in which the individual stations, such as sealing, coding, perforation and die-cutting, are configured in a way that saves space. Therefore, the N 950E only takes up a very small footprint in the primary packaging cleanroom, enabling space to be used to the max. All machine components are also easy to access, simplifying machine retooling and cleaning. What’s more, the use of servo technology ensures fast and reproducible format changes and reliable machine operation with high-quality end products. As a result, the N 950E meets all the requirements for outstanding OEE values, which can easily be read and evaluated on the HMI. The blister packaging machine can handle all sealable films – including sustainable mono-materials of PET, PP, PE and paper – and is equally capable of manufacturing aluminium-aluminium blisters. With its ingenious heating and cooling systems at the forming station and rotary sealing system, the machine can cope with all types of products and packaging materials. Configuration of the product feeding unit is also extremely flexible and takes place either with dedicated feeding, using a brush-box feeder or manually. Furthermore, the N 950E blister packaging machine is compatible with different transfer systems to the downstream cartoners, such as the Romaco Promatic PC 4201 continuous motion cartoner.
The N 950E is equipped with an AI-based vision inspection and pinhole detection system for blister packs. The 3D image analysis checks the tablets for various parameters, including presence, color, shape, breakage, etc. Moreover, this intelligent system inspects the packaging film for defects.
S 710 Prime double-sided rotary press from Romaco Kilian
The high-productivity S 710 Prime double-sided rotary press is suitable for both mono-layer and bi-layer mode. With a maximum output of 1,020,000 tablets per hour, the S 710 Prime is classed as a high-speed press for manufacturing pharmaceutical, food and chemical products – and is ideal for large batches and high volumes. It is an economical tablet press that convinces with excellent value for money and high overall equipment effectiveness (OEE) – the outcome of fast product changes, short cleaning times and long maintenance intervals. For example, durable pressure rollers result in significantly lower costs for maintenance. Owing to the interchangeable die-table, the S 710 Prime is very flexible. The proven fill shoe design and asymmetrical hoppers improve the product flow, so that the technology is similarly perfect for processing powders with poor flow properties. Furthermore, the wear-free brake magnet technology restricts the relative standard deviation during tableting to a minimum ensuring high product quality. The combination of precision-manufactured die-tables with hardly any radial run-out and the Kilian S 710 Prime’s magnetic product scrapers moreover enables a systematic reduction in product loss.
Ventilus Lab fluid bed processor by Romaco Innojet
To showcase its broad and varied portfolio of laboratory machines, Romaco will be presenting the Ventilus Lab fluid bed processor from Innojet. This exceptionally versatile all-rounder is used for granulating, drying and coating particles of any size from 10 μm to 2 mm. This multipurpose lab unit is intended for batch sizes from 0.7 to 7.0 liters. With its innovative process air distribution system inside the cylindrical product container, the required energy can be used far more efficiently, enabling the Ventilus Lab to cut batch processing times by up to 25%. The process air is introduced through the circular Orbiter booster, ensuring homogeneous flow conditions and gentle intermixing of the batch. In combination with a bottom spray nozzle located in the center, the booster plate forms a unique functional unit enabling much simpler scale-up processes. When it comes to nozzle technology, users can choose between the well-established Rotojet and the recently launched Flexijet, which was specifically developed for granulation processes and is both very easy to handle and quick to clean. The patented fluid bed components invented by Dr. h. c. Herbert Hüttlin are behind the remarkably accurate application of the spray liquid, with a precisely defined droplet size. With controlled release formulations, for instance, the modified release profiles are achieved using 10 to 15% less material. This targeted reduction in the amount of spray liquid used also means less power consumption, so that the Ventilus Lab substantially reduces CO2 emissions from fluid bed processes. Moreover, the rotating Sepajet filter system minimizes general product loss by returning particles retained by the filter to the process rather than discharging them.
